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Evolution of smell.... People are different.
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wiserd
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Evolution of smell.... People are different.
12-22-2012 4:14 PM

I came across this recently. It confirms that there's a remarkable amount of individual and racial variation in regards to how people experience smell. And because the receptors used for smelling things are the same the body uses internally, differences in olfaction should tell us something about a person's biology and how they might react to various drugs.


Quote:There is an enormous diversity in the repertoire of functional odorant receptor genes among different people. Roughly 60% of human odor receptor genes have mutated into non-functional pseudogenes in a relatively recent genomic process... These and earlier findings suggest that differing evolutionary pressures may have shaped the chemosensory repertoire in different human populations. Additional variation in the population may come from differences in gene expression. Experiments with custom microarrays specialized for detecting odor receptor genes have found that the expressed receptor repertoires of any pair of individuals differ by at least 14% [12], suggesting that polymorphisms exist not only in coding regions but also in promoter and other regulatory regions (Figure 1).

...
GPCRs are estimated to account for some 50% of the targets for drugs in current use. As the odor receptors are GPCRs, the demonstration of polymorphic variation in their function by Keller et al. [5] provides strong support for the likelihood that polymorphic variation in other GPCRs has important effects on drug efficacy and side effects.

https://genomebiology.com/2007/8/11/230

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12-22-2012 4:14 PM
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RE: Evolution of smell.... People are different.
12-22-2012 6:48 PM

Interesting.
I cant find the article, but i have read about an Australian medicine company who are in a stage where they test out a newly developed "Viagra" for women. It will come as a nose spray and will mostly consist of Testosterone. What they found is that smell of testosterone will turn a woman on almost instantly.
I cant find the article, so cant say much about it seriousity.
12-22-2012 6:48 PM
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jvkohl
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Post: #3
RE: Evolution of smell.... People are different.
12-27-2012 9:22 PM

(12-22-2012 6:48 PM)Q-Tips Wrote:  Interesting.
I cant find the article, but i have read about an Australian medicine company who are in a stage where they test out a newly developed "Viagra" for women. It will come as a nose spray and will mostly consist of Testosterone. What they found is that smell of testosterone will turn a woman on almost instantly.
I cant find the article, so cant say much about it seriousity.

As I recall, this was simply intranasal delivery of testosterone. Not necessarily the smell of testosterone, but its rapid absorption is responsible for the effect on libido.

James V. Kohl
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Author/Creator: The Scent of Eros
12-27-2012 9:22 PM
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RE: Evolution of smell.... People are different.
12-27-2012 9:32 PM

How keeping active pays off in the olfactory system

Although this is a technical representation, it accurately informs us about the essential role the development of olfactory receptor gene expression plays in our responses to novel odors, and why individual responses to odors vary with time and developmental staging. The bottom line is that "Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans." -- the concluding sentence from my most recently published review article. If not for the individual variation, there would be no such thing as adaptive evolution across species. In essence, nutrient chemical-dependent pheromone-controlled reproduction is more important to survival of the species than anything else, no matter what species is discussed. That's what makes discussion of human pheromones important at all levels of discussion, not just in discussion of how to improve someone's sex life (not that there's anything wrong with that!)

James V. Kohl
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12-27-2012 9:32 PM
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alphavitea
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RE: Evolution of smell.... People are different.
12-28-2012 12:26 AM

(12-27-2012 9:22 PM)jvkohl Wrote:  As I recall, this was simply intranasal delivery of testosterone. Not necessarily the smell of testosterone, but its rapid absorption is responsible for the effect on libido.


Isn't some of the pheromone being absorbed in the nose by just smelling it? Albeit in much smaller amounts?

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12-28-2012 12:26 AM
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RE: Evolution of smell.... People are different.
01-13-2013 2:09 PM

(12-27-2012 9:22 PM)jvkohl Wrote:  As I recall, this was simply intranasal delivery of testosterone. Not necessarily the smell of testosterone, but its rapid absorption is responsible for the effect on libido.

Pardon my ignorance, but as i understand, research find that the VNO in human arent active. So to get pheromoness to work, wouldnt pheromones have to go trough the same system as testosterone would have to, even tough effective enough to work even with just the smell? How can we tell testosterone wouldnt be effective enough with just the smell of it. And if not, would pheromones be even more effective than testosterone since the smell alone is good enough to influence the human brain?
Anyway, thanks for the input.
01-13-2013 2:09 PM
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jvkohl
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RE: Evolution of smell.... People are different.
01-13-2013 2:21 PM

(01-13-2013 2:09 PM)Q-Tips Wrote:  Pardon my ignorance, but as i understand, research find that the VNO in human arent active. So to get pheromoness to work, wouldnt pheromones have to go trough the same system as testosterone would have to, even tough effective enough to work even with just the smell? How can we tell testosterone wouldnt be effective enough with just the smell of it. And if not, would pheromones be even more effective than testosterone since the smell alone is good enough to influence the human brain?
Anyway, thanks for the input.

Pheromones and food odors act through the sense of smell; they effect hormones that affect behavior. Human pheromones: integrating neuroendocrinology and ethology Androgens, like testosterone, are hormones that affect behavior. Pheromones -- like female copulins -- effect male testosterone.

James V. Kohl
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Author/Creator: The Scent of Eros
01-13-2013 2:21 PM
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RE: Evolution of smell.... People are different.
01-20-2013 7:26 PM

(01-13-2013 2:21 PM)jvkohl Wrote:  Pheromones and food odors act through the sense of smell; they effect hormones that affect behavior. Human pheromones: integrating neuroendocrinology and ethology Androgens, like testosterone, are hormones that affect behavior. Pheromones -- like female copulins -- effect male testosterone.

Thanks, this is very interesting.
However, it makes me wonder. Considering pheromones act through the sense of smell. Wouldnt it be a bad mistake trying to cover the pheromones with other scents? Here we walk around being affraid someone would notice the bad smell from some of the pheromones, while the entire point is that we want them to get under our pheromone cloud.
Well, i guess i know that answer, as i think i got even better results from Scent of Eros with Musk than the unscented one.
01-20-2013 7:26 PM
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RE: Evolution of smell.... People are different.
01-20-2013 7:42 PM

(01-20-2013 7:26 PM)Q-Tips Wrote:  Well, i guess i know that answer, as i think i got even better results from Scent of Eros with Musk than the unscented one.

Linda got better results with the androsterone/androstenol mix when she repeated the study with sandalwood as a masking odor. I think I mentioned before that I had advised her against repeating the study but she did it on her own because others told her it should be done, when she first presented results at AChemS. This poster includes results from the replication.

https://f1000.com/posters/browse/summary/1387

James V. Kohl
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Author/Creator: The Scent of Eros
01-20-2013 7:42 PM
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