ok,
awhile since this thread was active, but, if I'm the first to find this little fact, then give me all your rep points and such. Ha.

Oxytocin has inhaled effects. The following link shows its inhaled effects on rhesus monkeys, voles & humans.
http://www.pnas.org/content/early/2012/0...9.full.pdf
http://www.pnas.org/content/early/2012/0...9.full.pdf

However, the method wasn't as sublime as wearing it with cologne, 25iu over 5 minutes to the nose/mouth. I'm not sure the equivalence of mg=iu with Oxytocin (OT).

With the monkeys, the difference with the added Oxytocin was a change in how the would reward. With the option to reward either
A) themself
B) nobody
C) another monkey

Quote:Inhaled oxytocin amplifies both vicarious
reinforcement and self reinforcement in
rhesus macaques (Macaca mulatta)

Steve W. C. Changa, Joseph W. Barterb, R. Becket Ebitza, Karli K. Watsona, and Michael L. Platta, Department of Neurobiology, Duke University School of Medicine, Durham, NC 27701; and Center for Cognitive Neuroscience and Departments of Evolutionary Anthropology and Psychology and Neuroscience, Duke University, Durham, NC 27708

Edited by Bruce S. McEwen, The Rockefeller University, New York, NY, and approved December 5, 2011 (received for review September 6, 2011)

People attend not only to their own experiences, but also to the
experiences of those around them. Such social awareness profoundly
influences human behavior by enabling observational learning, as
well as by motivating cooperation, charity, empathy, and spite.
Oxytocin (OT), a neurosecretory hormone synthesized by hypothalamic
neurons in the mammalian brain, can enhance affiliation or
boost exclusion in different species in distinct contexts, belying any
simple mechanistic neural model. Here we show that inhaled OT
penetrates the CNS and subsequently enhances the sensitivity of
rhesus macaques to rewards occurring to others as well as themselves.
Roughly 2 h after inhaling OT, monkeys increased the
frequency of prosocial choices associated with reward to another
monkey when the alternative was to reward no one. OT also
increased attention to the recipient monkey as well as the time it
took to render such a decision. In contrast, within the first 2 h
following inhalation, OT increased selfish choices associated with
delivery of reward to self over a reward to the other monkey,
without affecting attention or decision latency. Despite the differences
in species typical social behavior, exogenous, inhaled OT
causally promotes social donation behavior in rhesus monkeys, as
it does in more egalitarian and monogamous ones, like prairie voles
and humans, when there is no perceived cost to self. These findings
potentially implicate shared neural mechanisms.

I want to raise the question and garner insight and results as to if Oxytocin is P79, how it can act both ways, selfish and giving, depending on context. I need to see if a mix that used my P83 and P79 for disinhibiting(p83) and amplification of effect(p79) works with Alpha-THDOC & Oxytocin.

Feel free to chime in.

oh, and the hilarity of this organizational acronym needs some attention.

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Does PNAS sound funny to anybody else? I wonder how it would go in introductions at business meetings.
ex: "Hello, my name is Dick, I'm the head of PNAS" har har

(06-10-2013 9:07 PM)dexter Wrote:  ok,
awhile since this thread was active, but, if I'm the first to find this little fact, then give me all your rep points and such. Ha.

Oxytocin has inhaled effects. The following link shows its inhaled effects on rhesus monkeys, voles & humans.
http://www.pnas.org/content/early/2012/0...9.full.pdf
http://www.pnas.org/content/early/2012/0...9.full.pdf

However, the method wasn't as sublime as wearing it with cologne, 25iu over 5 minutes to the nose/mouth. I'm not sure the equivalence of mg=iu with Oxytocin (OT).

With the monkeys, the difference with the added Oxytocin was a change in how the would reward. With the option to reward either
A) themself
B) nobody
C) another monkey


I want to raise the question and garner insight and results as to if Oxytocin is P79, how it can act both ways, selfish and giving, depending on context. I need to see if a mix that used my P83 and P79 for disinhibiting(p83) and amplification of effect(p79) works with Alpha-THDOC & Oxytocin.

Feel free to chime in.

Oxytocin as p79. Interesting...
They do seem very similar. I might have gotten more of a Testosterone drop with oxytocin, but otherwise they feel just the same. Maybe it was a matter of dose...

(06-11-2013 12:08 AM)wiserd Wrote:  Oxytocin as p79. Interesting...
They do seem very similar. I might have gotten more of a Testosterone drop with oxytocin, but otherwise they feel just the same. Maybe it was a matter of dose...

don't forget the 2 hour mark thing that the paper described, that must be a time delay sort of reaction that changes a secondary internal hormone(s) level over the 2 hour timespan. They went from more giving in the 30min-2hour time, then more selfish after the 2hours mark.

The difference in social behavior due to Oxytocin (OT) exposure is significant because these monkeys normally DON'T SHARE!

Quote:Compared with some other nonhuman primates, social behavior
of rhesus monkeys is primarily characterized by competition and aggression, and shows very weak, if any, inclination toward cooperation.

Seems some monkeys are more giving than others, because they had real mommys. Seems like hormone levels throughout life can be learned and sometimes maintained at higher levels due to previous environmental variables like a real monkey mommy or breast milk hormone exposure.

Quote:In a prior study, different levels of endogenous OT were reported in more socially affiliative mother-reared compared with more socially agnostic nursery-reared macaques(monkeys).

I need to check out the references to human exposure to OT.

Quote:These findings are consistent with contextdependent
effects of OT on human social behavior (16, 17, 39)
(for a review of human social processing, see ref. 40), implying
similar neural mechanisms.

16. De Dreu CK, et al. (2010) The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science 328:1408–1411.
17. De Dreu CK, Greer LL, Van Kleef GA, Shalvi S, Handgraaf MJ (2011) Oxytocin promotes human ethnocentrism. Proc Natl Acad Sci USA 108:1262–1266.
39. Bartz JA, Zaki J, Bolger N, Ochsner KN (2011) Social effects of oxytocin in humans: Context and person matter. Trends Cogn Sci 15:301–309.
40. Fehr E, Fischbacher U (2003) The nature of human altruism. Nature 425:785–791.

Vasopressin, what is it, and if it is so close to oxytocin, is it of putative pheromone interest?

Quote:In
humans, intranasal delivery of a similar peptide, vasopressin (differing by only
two amino acids), increases its concentration in the CSF after 10 min, and elevated
vasopressin levels are maintained for more than 80 min after administration
(35).

35. Born J, et al. (2002) Sniffing neuropeptides: A transnasal approach to the human brain. Nat Neurosci 5:514–516.
21. Insel TR (2010) The challenge of translation in social neuroscience: A review of oxytocin, vasopressin, and affiliative behavior. Neuron 65:768–779.
22. Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nat Rev Neurosci 12:524–538.

Autism? ASD (Autism Spectrum Disorder)??? Who was Tacitus?????
I remember reading a post by Tacitus at AndDir's Forum where Tacitus said a certain molecule or mix removed ASD effects, and I think it was the [A314+P79+P83+Alpha Androstenol Tacitus ASD mix]?, he also mentioned Anal Sex in his post and at the time I didn't know what ASD was so I thought the A&S in ASD was Anal Sex, but it isn't as I later found out, it has to do with Autism, and maybe Asperger's (haha Asperger's sounds funny, cacapoopoo). The references in the paper point to Oxytocin and it's effects on Autism, Tacitus refered to mixes containing P79 & other putatives having an effect on Autism(ASD's).

Quote:Tacitus October 9th, 2006, 07:03 AM
Re: The good Putatives so far
Tacitus @ AndDir Forum ASD mention

Dunno exactly.... played around with P79 / P83 in a base of a -nol , a-Androsterone, and TAA .... the 79/83 combo has repeatedly led to passionate, greasy pig sex... women seem to lose all their ASD barriers with 79/83 ... they just... get... into... it...

Quote:Tacitus November 2nd, 2007, 09:49 AM
Re: Whats your most BRUTAL hit?
http://www.pheromonetalk.com/mens-pherom...#post71895

Female friend of mine and her current BF walked up to me shit faced drunk the both of them and demanded I go home with them for three way... was not going to happen ... they were so insistent I practically had to shove them into a cab and hold the door shut with my foot until it drove off... next time I saw them they were sort of mortified, in denial, acted as if it had never happened...

Personal Code Of Conduct: never have sex with someone who is drunk or high unless you know that person wouldn't have an issue being sexual stone cold sober... or, never underestimate the power of the ASD , especially in "well bred little angels" who want to try on their bad girl costume... I much prefer sluts who are fully conscious and at one with their slutness and have high self esteem and have integrated the erotocism with their total sense of self...

Quote:tacitus (December 16, 2006)
P79 + P83 with bright shiny mones in the background
http://www.pheromonetalk.com/mens-pherom...#post15718

Woooooo.... that was..... XXX rated.... I had two mixes, one was 50 Microgram P79 + 50 Microgram P83... the other was an A314, Alpha Androstenol , TAA love'n'happiness blend.... so I'm with this awesome somewhat older, intensely hot creature, and I give her a biggg whiff of the P79+P83 and she looks like she's about to spontaneously combust... then on went the love'n'happiness mixture.... alright... if you have tender sensibilities, stop reading NOW.... cover your eyes... this is the third time in rapid sucession that (three different, all unalike) have women have wanted, and passionately enjoyed.... ahem...... anal sex..... OK... there.... I said it... now, as.... cough... adults..... we all know that porno-grade sex potions are the fodder of the dumbest adolescent fantasies.... a more nuanced interpretation is that women (more that would freely admit it) do, in fact, have libidos that are as strong and (potentially) uninhibitedly raunchy as the typical horny, raunchy male.... however.... women are also subject to much heavier socialization about "good girl" versus "she devil" erotocism.... wherein she devil levels of desire may be perceived as socially destabilizing..... like, when a known she devil shows up on the scene, you notice how the Precious Pure Angels circle their wagons and freak out.... yeah... I thought so.... you know exactly what I'm talking about.... because the Precious Pure Angels know all too well what the menfolk are fantasizing when the She Devil is present... soooooo.... the girly girls learns the wisdom of shutting it down and covering it up.... oooooh yes, my husband and I.... on Sundays, after church.... after consulting our higher powers, lay down on white linens and whisper naughty things to each other.... so..... your humble Tacitus has concluded that, under the right circumstances, these troubling ASDs can be overridden and the She Devilcomes out to play..... unlike her Precious Pure Angel identity.... she is given to saying things like.... Dude, grease me up and f#$% me hard in the...... so wrong, so filthy, so real....

Quote:23. Andari E, et al. (2010) Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci USA 107:4389–4394.
24. Hollander E, et al. (2007) Oxytocin increases retention of social cognition in autism. Biol Psychiatry 61:498–503.
25. Baron-Cohen S, Leslie AM, Frith U (1985) Does the autistic child have a “theory of mind”? Cognition 21:37–46.

Does Reference #25 cite "BORAT"? (Sasha Baron-Cohen)??? haha.