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Oxytocin
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WhiteNoise309
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Post: #81
RE: Oxytocin
05-13-2015 3:13 PM

Great info. I don't think it more clear.
Now that I know what to look for I'm finding as lot more information about this. I have to be careful to avoid the hearsay and misinformation (a lot of it) and stick with reputable sources like the one you referred to.

This lays to rest a the speculation and misinformation on my part and arguments of whether or not it can work phenomenally. I stand corrected. But this also actually raises even more questions which I hope to find answers to.

If we have Oxytocin receptors in the nasal bulb to pick up what others breath, then that would suggest (I'm speculating) two things:
1) If it's transmitted from breath to the target's nasal bulb receptors, you a very small amount would be effective. I also haven't ever heard of someone breathing out enough Oxytocin to cause contractions in nearby women (but that doesn't mean it hasn't happened.) So what we exhale is probably not a high level and just to trigger intimacy.
Speculation: We are rather sensitive to small amounts.
2) The purpose of the nasal bulb receptors is to deliver that to the brain (like any other pheromone) specifically for the desired phycological effects. That is as opposed to the receptors in the uterus or breasts which have local affects of contractions or lactation. I'm not sure where physical skin sensitivity comes from (brain or receptors in the nervous system.)
Speculation: Nasal bulb receptors are the ideal target.

Sorry I ever doubted it.

This makes me rather enthusiastic to research it more.
I had one positive test where I wore it and my wife kissed and hugged me somewhat unexpectedly. It was hard to tell if that had anything to do with the Oxytocin I had just put on but that's often the case with any pheromone (coincidence, placebo, or a genuine hit.)

Question. How do you wear it? Do you just put the dropper on your skin and where?
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05-13-2015 3:13 PM
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dexter
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Post: #82
RE: Oxytocin
05-13-2015 4:15 PM

I usually wear it by putting 1 or 2 sprays of liquid trust on my wrists and then wiping it around my neck and hair. The same way I usually apply all my 'mones.

sorry for the wikipedia reference, but it seemed good enough.

Quote:http://en.wikipedia.org/wiki/Oxytocin

Mechanism of action

Oxytocin is destroyed in the gastrointestinal tract, so it must be administered by injection or as nasal spray. It has a half-life of typically about three minutes in the blood when given intravenously. When administered intranasally via a nasal spray, oxytocin crosses the blood–brain barrier and exhibits psychoactive effects in humans.[103][104] Unlike the case of intravenous administration, intranasal oxytocin has a duration of at least 2.25 hours and as long as 4 hours.[1][2]

[1] Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology 37 (9): 1582–6. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.
[2] Huffmeijer R, Alink LR, Tops M et al. (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinol. Lett. 33 (1): 21–5. PMID 22467107.
[3] Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 7: Neuropeptides". In Sydor A, Brown RY. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 195. ISBN 9780071481274. "Oxytocin can be delivered to humans via nasal spray following which it crosses the blood–brain barrier. ... In a double-blind experiment, oxytocin spray increased trusting behavior compared to a placebo spray in a monetary game with real money at stake."
[4] McGregor IS, Callaghan PD, Hunt GE (May 2008). "From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?". Br. J. Pharmacol. 154 (2): 358–368. doi:10.1038/bjp.2008.132. PMC 2442436. PMID 18475254. "Recent studies also highlight remarkable anxiolytic and prosocial effects of intranasally administered OT in humans, including increased ‘trust’, decreased amygdala activation towards fear-inducing stimuli, improved recognition of social cues and increased gaze directed towards the eye regions of others (Kirsch et al., 2005; Kosfeld et al., 2005; Domes et al., 2006; Guastella et al., 2008)."

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(This post was last modified: 05-13-2015 4:16 PM by dexter.)
05-13-2015 4:15 PM
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Post: #83
RE: Oxytocin
06-24-2015 11:05 PM

Has anyone noticed a relationship between oxytocin and alcohol consumption? I know that it's supposed to lessen the effects of alcohol in rats. I may have noticed it influencing people to drink more. I'm wondering if anyone has seen something similar.

[Image: Example.jpg]
06-24-2015 11:05 PM
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siddie
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Post: #84
RE: Oxytocin
09-30-2015 11:22 AM

Interesting to read about oxytocin as a pheromone here.

I've been using it to treat my aspergers for almost 3 years now. It helps me feel emotions, be social and vibe with other people. Great stuff.

I use 10IU medical Oxytocin (=20mcg), injected s.c., twice a day, which gives very noticeable effects in less than a minute. With 20mcg I blush, a slight feeling of love, puts me in a dreamy state. Even with low doses like 2mcg I can tell something is there.

When using more it gets quite intense, red face/skin, erection, deep feeling of love, sometimes trippy, feels like waves floating through my body, orgasm-like, but different.

To test if it works as a pheromone I took 200mcg (in injectable solution) and applied it to my neck/wrists. Noticed some self effects, maybe comparable to like 10mcg, but no apparent hits. Spent only ~3 hours in public, maybe not enough to tell for sure.

Today I applied the same amount to my shirt, just to exclude adsorption through skin. No / very slight self effects, no more hits compared to no mones also.

Maybe the molecule is just too big or needs some kind of diffusion system, who knows. If it works it will be awesome!
09-30-2015 11:22 AM
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Ekscentra
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Post: #85
RE: Oxytocin
09-30-2015 12:01 PM

Try mixing it with Iso E Super and Perfumer's Alcohol, the IES being at about 8-15% of the fragrance concentrate.

How long do you find Oxytocin lasts? I've been putting off testing it for my own Asperger's mostly because of the half-life.
(This post was last modified: 09-30-2015 12:01 PM by Ekscentra.)
09-30-2015 12:01 PM
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siddie
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Post: #86
RE: Oxytocin
09-30-2015 12:17 PM

(09-30-2015 12:01 PM)Ekscentra Wrote:  Try mixing it with Iso E Super and Perfumer's Alcohol, the IES being at about 8-15% of the fragrance concentrate.

How long do you find Oxytocin lasts? I've been putting off testing it for my own Asperger's mostly because of the half-life.

Will try that.

The initial blushing and dreamy effects last for max. 10 minutes, the emotions stay much longer, about 6 hours. When redosing after that I only need half the initial dose for another 6 hours of solid emotions Blush
09-30-2015 12:17 PM
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Post: #87
RE: Oxytocin
09-30-2015 12:32 PM

(09-30-2015 12:17 PM)siddie Wrote:  Will try that.

The initial blushing and dreamy effects last for max. 10 minutes, the emotions stay much longer, about 6 hours. When redosing after that I only need half the initial dose for another 6 hours of solid emotions Blush
Sounds about perfect. Just two doses a day then. I'll have to give it a shot, in that case.

If not, I can always test out Carbetocin.
09-30-2015 12:32 PM
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Post: #88
RE: Oxytocin
05-02-2016 5:43 AM

http://www.ncbi.nlm.nih.gov/pubmed/12167772

An intresting study, indicating (without actually stating that) excretion and subsequent pheromonal-activity of Oxytocin in rats.
05-02-2016 5:43 AM
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Post: #89
RE: Oxytocin
12-22-2016 12:28 PM

Here is an interesting article on Oxytocin as a "Youth" hormone.

http://phenomena.nationalgeographic.com/...-oxytocin/

another article on oxytocin as an empathy-communication hormone, often administered nasally.

https://www.scientificamerican.com/artic...-oxytocin/

dexter
"Think not that I am come to send peace on earth: I came not to send peace, but a sword." -Jesus, Matthew 10:34
AD-Glace, Certo, DHEAS, single mols
AD-a314,P74,5,6,8,9,P80,1,3,P93,5,6,7,P100,​1,2,3,4,9,12,23,25,IFM,
IG,IH,IJ,IO,IS,ISA,ISB,TUTH,TAA,C,F,H,K,​L,NONE,ANOL,AMMO,MX297,391-5UF
LS-LIQTRUST,NOL,NONE,RONE,A1,PERCEPTION,AE,​SOE
P7-ATJ,FTL,DG!,MAP,GG,PURSUIT,SB,TJ
TP-TLOVE,EST,MEO-EST,TJERK,TALPHA,A1,ATRIONE,COPS
HM-ETRIONE
HOMEBREW-D3,DHEA,PEA,ETRIONE,NENO,MEL
(This post was last modified: 12-22-2016 12:34 PM by dexter.)
12-22-2016 12:28 PM
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